Addanki P Kumar Selected Research

Nexrutine

10/2018	Suppression of ribosomal protein RPS6KB1 by Nexrutine increases sensitivity of prostate tumors to radiation.
10/2017	Combination of Nexrutine and docetaxel suppresses NFκB-mediated activation of c-FLIP.
3/2014	Combined targeting of STAT3/NF-κB/COX-2/EP4 for effective management of pancreatic cancer.
3/2010	Phellodendron amurense bark extract prevents progression of prostate tumors in transgenic adenocarcinoma of mouse prostate: potential for prostate cancer management.
4/2009	Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells.
11/2007	Regulation of Cox-2 by cyclic AMP response element binding protein in prostate cancer: potential role for nexrutine.
5/2007	Akt/cAMP-responsive element binding protein/cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by Nexrutine, a Phellodendron amurense bark extract.
6/2006	Akt-and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine, a Phellodendron amurense extract.

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Addanki P Kumar Research Topics

Disease

31	Neoplasms (Cancer) 01/2022 - 05/2003
23	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 05/2003
7	Adenocarcinoma 11/2016 - 02/2006
5	Pancreatic Neoplasms (Pancreatic Cancer) 10/2018 - 03/2014
4	Melanoma (Melanoma, Malignant) 03/2015 - 04/2003
3	Carcinogenesis 01/2022 - 01/2013
2	Inflammation (Inflammations) 10/2014 - 05/2009
2	Body Weight (Weight, Body) 01/2013 - 02/2006
2	Prostatic Intraepithelial Neoplasia 03/2010 - 05/2009
1	Disease Progression 01/2022
1	Chronic Disease (Chronic Diseases) 01/2022
1	Fatigue 01/2022
1	Obesity 01/2019
1	Glioma (Gliomas) 10/2018
1	Urogenital Neoplasms 04/2015
1	Fibrosis (Cirrhosis) 03/2014
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2013

Drug/Important Bio-Agent (IBA)

10	AndrogensIBA 10/2021 - 06/2006
9	2-MethoxyestradiolIBA 10/2021 - 02/2003
9	Proteins (Proteins, Gene)FDA Link 02/2021 - 01/2009
8	NexrutineIBA 10/2018 - 06/2006
5	Hormones (Hormone)IBA 01/2020 - 02/2006
4	Transcription Factors (Transcription Factor)IBA 10/2017 - 05/2003
4	DNA (Deoxyribonucleic Acid)IBA 04/2015 - 02/2006
4	NF-kappa B (NF-kB)IBA 03/2010 - 02/2003
3	EugenolIBA 10/2021 - 02/2005
3	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 02/2021 - 10/2017
3	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 05/2009
3	CytokinesIBA 01/2020 - 05/2009
3	quinone (benzoquinone)IBA 01/2020 - 05/2009
3	Gemcitabine FDA Link 10/2018 - 11/2016
2	ResveratrolIBA 01/2022 - 01/2013
2	NAD (NADH)IBA 01/2022 - 01/2020
2	Sirtuin 1IBA 01/2022 - 01/2013
2	RON proteinIBA 02/2021 - 01/2019
2	Apoptosis Regulatory ProteinsIBA 10/2017 - 01/2012
2	BerberineIBA 01/2017 - 04/2009
2	Estrogens (Estrogen)FDA Link 05/2015 - 01/2009
2	PhytochemicalsIBA 04/2015 - 03/2010
2	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2015 - 05/2014
2	EnzymesIBA 10/2014 - 05/2009
2	AntioxidantsIBA 10/2014 - 05/2009
2	Caspase 1 (ICE Protease)IBA 09/2014 - 03/2009
2	Biological ProductsIBA 03/2014 - 04/2009
2	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 03/2010 - 11/2007
2	Phosphotransferases (Kinase)IBA 01/2009 - 06/2006
2	Carrier Proteins (Binding Protein)IBA 05/2007 - 06/2006
2	Mercaptoethanol (2 Mercaptoethanol)IBA 04/2003 - 02/2003
1	Messenger RNA (mRNA)IBA 02/2021
1	Androgen Receptors (Androgen Receptor)IBA 01/2019
1	E2F1 Transcription FactorIBA 01/2019
1	Protein CIBA 01/2019
1	Prostate-Specific Antigen (Semenogelase)IBA 01/2019
1	Glutamine (L-Glutamine)FDA Link 10/2018
1	palmatineIBA 10/2018
1	SurvivinIBA 10/2018
1	Ribosomal Proteins (Ribosomal Protein)IBA 10/2018
1	Collagen Type I (Type I Collagen)IBA 10/2018
1	RNA (Ribonucleic Acid)IBA 01/2018
1	CollagenIBA 12/2017
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 10/2017
1	Docetaxel (Taxotere)FDA Link 10/2017
1	LuciferasesIBA 11/2016
1	matrigelIBA 11/2016
1	Protein Isoforms (Isoforms)IBA 11/2016
1	AlkaloidsIBA 12/2015
1	protoberberineIBA 12/2015
1	FlavonoidsIBA 04/2015
1	Cysteine (L-Cysteine)FDA Link 03/2015
1	Glutathione Disulfide (GSSG)FDA LinkGeneric 03/2015
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 03/2015
1	Mechanistic Target of Rapamycin Complex 1IBA 03/2015
1	Interleukin-8 (Interleukin 8)IBA 10/2014
1	ProstaglandinsIBA 03/2014
1	Prostaglandin Receptors (Prostaglandin Receptor)IBA 03/2014
1	Biomarkers (Surrogate Marker)IBA 01/2012
1	Pharmaceutical PreparationsIBA 05/2011
1	QuercetinIBA 05/2011
1	4-methylcatecholIBA 05/2011
1	AgarIBA 05/2011
1	ChemokinesIBA 05/2009
1	Chemotactic FactorsIBA 05/2009
1	NADP (NADPH)IBA 05/2009
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 05/2009
1	NF-KappaB Inhibitor alphaIBA 04/2009
1	Butanols (Butyl Alcohols)IBA 04/2009
1	Cyclin D1IBA 05/2007
1	ElementsIBA 05/2007
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2006
1	isoeugenolIBA 02/2005
1	E2F Transcription FactorsIBA 02/2005
1	A 19IBA 02/2005
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 05/2003

Therapy/Procedure

10	Therapeutics 01/2022 - 02/2005
3	Prostatectomy (Retropubic Prostatectomy) 01/2022 - 01/2012
2	Radiotherapy 10/2018 - 12/2015
1	Drug Therapy (Chemotherapy) 11/2016
1	Complementary Therapies (Alternative Medicine) 05/2010
1	Oral Administration 01/2009
1	Plant-Based Diet 06/2006